Enamel matrix derivative promotes new bone formation in xenograft assisted maxillary anterior ridge preservation—A randomized controlled clinical trial

Objectives To compare the effectiveness of deproteinized bovine bone mineral with 10% collagen alone (DBBMC) or enamel matrix derivative (DBBMC-EMD) in ridge preservation. Methods 42 maxillary anterior teeth were extracted and received either a DBBMC (control) DBBMC-EMD (test) treatment protocol. CBCT taken before 4 months after extraction procedure was used to measure changes alveolar width (RW), buccal height (BH) palatal (PH). Bone cores harvested during implant osteotomy preparation, samples processed histomorphometrically assess fraction new (%NB), residual graft (%RG) soft tissue (%STM). Results Overall, both groups showed significant reductions mean RW from baseline extraction, but no change BH PH over this time. When measurements analysed according initial thickness wall (BT < 1 mm vs. BT ? mm), all dimensions (RW, PH) noted <1 group. Histomorphometrically, test group significantly increased formation (%NB): (control = 16.5 ± 6.9% cf.; 45.1 8.8%) less (%RG): 36.8 8.8% 20.3 7.2%) compared control Conclusions Both treated sites lost PH. Irrespective treatment, thick walls (?1 mm) exhibited reduction treatment. The addition EMD resulted more